Genetic consequences of tolerance to methylation DNA damage in mammalian cells.

doi:10.1093/carcin/14.10.2097

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Genetic consequences of tolerance to methylation DNA damage in mammalian cells.

Carcinogenesis - 1 Oct 1993

Aquilina G, Biondo R, Dogliotti E, Bignami M

Abstract excerpt

We previously characterized a clone of CHO cells, clone B, that displayed tolerance to the cytotoxic effects of N-methylnitrosourea (MNU) and 6-thioguanine (6-TG). To determine whether this phenotype affected the mutagenic response of the cells, MNU-induced mutation to 8-azaadenine resistance (8-AAr) was measured in the parental and clone B cells. Comparable mutation frequencies were found in the two cell lines...

Topics

Adenine
Adenine Phosphoribosyltransferase
Animals
Aza Compounds
Base Sequence
CHO Cells
Cell Survival
Cricetinae
DNA
DNA Damage
Drug Resistance
Guanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylation

Methylnitrosourea

Molecular Sequence Data

Mutation

Ouabain

Thioguanine

Source

Open in PubMed

Identifiers

PMID: 8222060
DOI: 10.1093/carcin/14.10.2097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8222060-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic consequences of tolerance to methylation DNA damage in mammalian cells.PMID 8222060Read ↗

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.Semantic proximity Read ↗

A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.Semantic proximity Read ↗

Spontaneous mutations at aprt locus in a mammalian cell line defective in mismatch recognition.Semantic proximity Read ↗

Strand- and sequence-specific attenuation of N-methyl-N'-nitro-N-nitrosoguanidine-induced G.C to A.T transitions by expression of human 6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells.Semantic proximity Read ↗

Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.Semantic proximity Read ↗

DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells.Semantic proximity Read ↗

A human cell line proficient in O6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents.Semantic proximity Read ↗

Tolerance to O6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosourea-resistant Chinese hamster ovary cells.Semantic proximity Read ↗

Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines.Semantic proximity Read ↗

Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11.Semantic proximity Read ↗

Quantitative relationship between ethylated DNA bases and gene mutation at two loci in CHO cells.Semantic proximity Read ↗

Toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.