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Article

Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair.

Journal of molecular biology - 6 Mar 1998

Ciotta C, Ceccotti S, Aquilina G, Humbert O, Palombo F, Jiricny J, Bignami M

Abstract excerpt

We have studied whether spontaneous intrachromosomal recombination is altered in methylation tolerant human cells with a defect in mismatch repair. Somatic recombination was analysed in HeLaMR cells containing the vector pTPSN, which carries two copies of the gene for hygromycin resistance. The hygromycin genes are both inactivated by an inserted HindIII linker but hygromycin-resistant clones can arise by...

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Identifiers

PMID: 9500919
DOI: 10.1006/jmbi.1997.1559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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