Article
Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair.
Journal of molecular biology - 6 Mar 1998
Ciotta C, Ceccotti S, Aquilina G, Humbert O, Palombo F, Jiricny J, Bignami M
Abstract excerpt
We have studied whether spontaneous intrachromosomal recombination is altered in methylation tolerant human cells with a defect in mismatch repair. Somatic recombination was analysed in HeLaMR cells containing the vector pTPSN, which carries two copies of the gene for hygromycin resistance. The h...
Topics
- Base Sequence
- Cinnamates
- DNA
- DNA Methylation
- DNA Primers
- DNA Repair
- Drug Resistance, Microbial
- Gene Conversion
- Genetic Vectors
- HeLa Cells
- Humans
- Hygromycin B
- Hypoxanthine Phosphoribosyltransferase
- Methylnitronitrosoguanidine
- Microsatellite Repeats
- Mutation
- Plasmids
- Recombination, Genetic