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Article

No evidence of linkage between the dopamine D2 receptor gene and schizophrenia.

Psychiatry research - 1 Aug 1994

Hallmayer J, Maier W, Schwab S, Ertl M A, Minges J, Ackenheil M, Lichtermann D, Wildenauer D B

Abstract excerpt

The antipsychotic effects of dopamine D2 receptor antagonists (neuroleptics) and the psychotomimetic effects of dopamine agonists suggest that a defect of the D2 receptor gene might be a factor in the etiology of schizophrenia. Fifteen families that contained several members suffering from schizophrenia were tested for linkage between the D2 receptor gene and schizophrenia. In addition, four flanking markers were...

Topics

Bipolar Disorder
DNA Probes
Genes, Dominant
Genes, Recessive
Genetic Linkage
Genetic Markers
Genotype
Humans
Mutation
Phenotype
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Psychotic Disorders

Receptors, Dopamine D2

Risk Factors

Schizophrenia

Schizophrenic Psychology

Source

Identifiers

PMID: 7824680
DOI: 10.1016/0165-1781(94)90111-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7824680-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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No evidence of linkage between the dopamine D2 receptor gene and schizophrenia.PMID 7824680Read ↗

Exclusion of linkage between schizophrenia and the D2 dopamine receptor gene region of chromosome 11q in 112 Irish multiplex families.Semantic proximity Read ↗

Absence of linkage between schizophrenia and the dopamine D4 receptor gene.Semantic proximity Read ↗

Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia.Semantic proximity Read ↗

Linkage analysis of schizophrenia: the D1 dopamine receptor gene and several flanking DNA markers.Semantic proximity Read ↗

Alleles at the dopamine D4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred.Semantic proximity Read ↗

No association or linkage between the 5-HT2a/T102C polymorphism and schizophrenia in Irish families.Semantic proximity Read ↗

Linkage analysis between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene.Semantic proximity Read ↗

Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia.Semantic proximity Read ↗

Exclusion of close linkage of the dopamine transporter gene with schizophrenia spectrum disorders.Semantic proximity Read ↗

Multicenter linkage study of schizophrenia loci on chromosome 22q.Semantic proximity Read ↗

Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred.Semantic proximity Read ↗

Report from the Maryland Epidemiology Schizophrenia Linkage Study: no evidence for linkage between schizophrenia and a number of candidate and other genomic regions using a complex dominant model.Semantic proximity Read ↗

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