Article
Multicenter linkage study of schizophrenia loci on chromosome 22q.
Molecular psychiatry - 1 Aug 2004
Mowry B J, Holmans P A, Pulver A E, Gejman P V, Riley B, Williams N M, Laurent C, Schwab S G, Wildenauer D B, Bauché S, Owen M J, Wormley B, Sanders A R, Nestadt G, Liang K Y, Duan J, Ribble R, Norton N, Soubigou S, Maier W, Ewen-White K R, DeMarchi N, Carpenter B, Walsh D, Williams H, Jay M, Albus M, Nertney D A, Papadimitriou G, O'Neill A, O'Donovan M C, Deleuze J-F, Lerer F B, Dikeos D, Kendler K S, Mallet J, Silverman J M, Crowe R R, Levinson D F
Abstract excerpt
The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.