Article
Linkage analysis of schizophrenia: the D1 dopamine receptor gene and several flanking DNA markers.
Human heredity - 1 Jan 2000
Jensen S, Plaetke R, Holik J, Hoff M, Myles-Worsley M, Leppert M, Coon H, Vest K, Freedman R, Waldo M
Abstract excerpt
Alterations in dopaminergic activity may play an important role in the pathogenesis of schizophrenia. The central effects of dopamine are mediated by at least five G protein-coupled receptors, D1, D2, D3, D4 and D5. The D1 receptor maps to 5q35.1 and it identifies an Eco RI as well as a Taq I RFL...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Phenotype
- Receptors, Dopamine D1
- Schizophrenia