Article
Exclusion of linkage between schizophrenia and the D2 dopamine receptor gene region of chromosome 11q in 112 Irish multiplex families.
Archives of general psychiatry - 1 Mar 1993
Su Y, Burke J, O'Neill F A, Murphy B, Nie L, Kipps B, Bray J, Shinkwin R, Ni Nuallain M, MacLean C J
Abstract excerpt
A leading theory hypothesizes that schizophrenia arises from dysregulation of the dopamine system in certain brain regions. As this dysregulation could arise from abnormal expression of D2 dopamine receptors, the D2 receptor gene (DRD2) on chromosome 11q is a candidate locus for schizophrenia. We...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Genetic Linkage
- Genetic Variation
- Humans
- Ireland
- Models, Genetic
- Receptors, Dopamine
- Schizophrenia