Article
Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia.
American journal of medical genetics - 15 Mar 1994
Shaikh S, Gill M, Owen M, Asherson P, McGuffin P, Nanko S, Murray R M, Collier D A
Abstract excerpt
We report the results of a linkage study in 24 families multiply affected with schizophrenia using a polymorphic DNA sequence encoding the third cytoplasmic loop of the dopamine D4 receptor. Two-point LOD score analyses with a range of single gene models ranging from near dominant to near recessi...
Topics
- Alleles
- Base Sequence
- Chromosomes, Human, Pair 11
- DNA Primers
- Family Health
- Genetic Linkage
- Humans
- Lod Score
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, Dopamine
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Repetitive Sequences, Nucleic Acid
- Schizophrenia