Article
Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred.
Archives of general psychiatry - 1 Apr 1994
Macciardi F, Petronis A, Van Tol H H, Marino C, Cavallini M C, Smeraldi E, Kennedy J L
Abstract excerpt
BACKGROUND: Among the different dopamine receptors, the D4 dopamine receptor is of particular interest in schizophrenia because of its high affinity for the atypical neuroleptic clozapine. Recently, the gene for the D4 dopamine receptor has been cloned and a new and intriguing polymorphism has be...
Topics
- Blotting, Southern
- Family
- Genetic Linkage
- Genetic Variation
- Humans
- Italy
- Lod Score
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, Dopamine
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Schizophrenia
- Tyrosine 3-Monooxygenase