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Article

Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred.

Archives of general psychiatry - 1 Apr 1994

Macciardi F, Petronis A, Van Tol H H, Marino C, Cavallini M C, Smeraldi E, Kennedy J L

Abstract excerpt

BACKGROUND: Among the different dopamine receptors, the D4 dopamine receptor is of particular interest in schizophrenia because of its high affinity for the atypical neuroleptic clozapine. Recently, the gene for the D4 dopamine receptor has been cloned and a new and intriguing polymorphism has been described. Different versions of the receptor have varying affinity for clozapine, and thus variant froms of D4 with...

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Identifiers

PMID: 7909222
DOI: 10.1001/archpsyc.1994.03950040032004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred.PMID 7909222Read ↗

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Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia.Semantic proximity Read ↗

Multiple dopamine D4 receptor variants in the human population.Semantic proximity Read ↗

Linkage analysis of schizophrenia: the D1 dopamine receptor gene and several flanking DNA markers.Semantic proximity Read ↗

Absence of linkage between schizophrenia and the dopamine D4 receptor gene.Semantic proximity Read ↗

Dopamine D4 receptor variants in unrelated schizophrenic cases and controls.Semantic proximity Read ↗

Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk variant with clozapine response.Semantic proximity Read ↗

Association study of a null mutation in the dopamine D4 receptor gene in Italian patients with obsessive-compulsive disorder, bipolar mood disorder and schizophrenia.Semantic proximity Read ↗

Exclusion of linkage between schizophrenia and the D2 dopamine receptor gene region of chromosome 11q in 112 Irish multiplex families.Semantic proximity Read ↗

No evidence of linkage between the dopamine D2 receptor gene and schizophrenia.Semantic proximity Read ↗

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