Article
Linkage analysis between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene.
Psychiatric genetics - 1 Jan 1994
Ravindranathan A, Coon H, DeLisi L, Holik J, Hoff M, Brown A, Shields G, Crow T, Byerley W
Abstract excerpt
Using 23 multiplex pedigrees we tested for linkage between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene (DRD5). Assuming autosomal dominant inheritance and a maximum penetrance of 0.6, an overall lod score of -4.54 was derived at 0% recombination. For recessive transmission the summary lod score was -8.37 at 0% recombination. These data suggest that mutations of the D5...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.