Article
Linkage analysis between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene.
Psychiatric genetics - 1 Jan 1994
Ravindranathan A, Coon H, DeLisi L, Holik J, Hoff M, Brown A, Shields G, Crow T, Byerley W
Abstract excerpt
Using 23 multiplex pedigrees we tested for linkage between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene (DRD5). Assuming autosomal dominant inheritance and a maximum penetrance of 0.6, an overall lod score of -4.54 was derived at 0% recombination. For recessiv...
Topics
- Adolescent
- Adult
- DNA, Satellite
- Genetic Linkage
- Genotype
- Humans
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, Dopamine
- Receptors, Dopamine D1
- Receptors, Dopamine D5
- Schizophrenia