Article
Absence of linkage between schizophrenia and the dopamine D4 receptor gene.
Psychiatry research - 1 Jul 1994
Maier W, Schwab S, Hallmayer J, Ertl M A, Minges J, Ackenheil M, Lichtermann D, Wildenauer D
Abstract excerpt
The dopamine D4 receptor gene and the closely placed tyrosine hydroxylase (TH) receptor gene are important candidate genes for schizophrenia; both are located on the short arm of chromosome 11. Multipoint linkage analyses excluded linkage of schizophrenia/schizoaffective disorder to both candidate genes in a sample of 15 multiplex and systematically recruited families. This result was not dependent on the...
Topics
- Genes, Dominant
- Genes, Recessive
- Genetic Linkage
- Genetic Markers
- Humans
- Phenotype
- Polymerase Chain Reaction
- Receptors, Dopamine
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Risk Factors