Article
Alleles at the dopamine D4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred.
American journal of medical genetics - 15 Dec 1993
Barr C L, Kennedy J L, Lichter J B, Van Tol H H, Wetterberg L, Livak K J, Kidd K K
Abstract excerpt
The discovery of a functional polymorphism within the dopamine D4 receptor gene (DRD4) has not only strengthened the hypotheses implicating DRD4 in the etiology of neuropyschiatric disorders, but also provided a genetic marker for testing these hypotheses. The possibility of the dopamine D4 receptor as a candidate gene for schizophrenia was investigated in a large Swedish kindred segregating for schizophrenia....
Topics
- Alleles
- Chromosome Mapping
- Disease Susceptibility
- Female
- Genetic Linkage
- Humans
- Male
- Pedigree
- Receptors, Dopamine
- Receptors, Dopamine D2
- Receptors, Dopamine D4