Mechanisms that limit the diversity of antibodies. II. Evolutionary conservation of Ig variable region genes which encode naturally occurring autoantibodies.

doi:10.1093/intimm/6.9.1427

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mechanisms that limit the diversity of antibodies. II. Evolutionary conservation of Ig variable region genes which encode naturally occurring autoantibodies.

International immunology - 1 Sept 1994

Booker J K, Haughton G

Abstract excerpt

Antibody which reacts with phosphatidyl choline can be detected in all normal mice. Generation of this specificity requires the use of either the unmutated VH11 or VH12 genes, with constraints on the length and sequence of CDR3, and specific light chain association. Given that those parts of the...

Topics

Alleles
Amino Acid Sequence
Animals
Antibody Diversity
Autoantibodies
B-Lymphocytes
Base Sequence
Biological Evolution
DNA Primers
DNA Probes
Genes, Immunoglobulin
Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Mice

Mice, Inbred Strains

Molecular Sequence Data

Phosphatidylcholines

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 7819152
DOI: 10.1093/intimm/6.9.1427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7819152-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms that limit the diversity of antibodies. II. Evolutionary conservation of Ig variable region genes which encode naturally occurring autoantibodies.PMID 7819152Read ↗

Structure and evolution of mammalian V<sub>H</sub> familiesSemantic proximity Read ↗

Antibody repertoires generated by VH replacement and direct VH to JH joining.Semantic proximity Read ↗

Frequent occurrence of identical heavy and light chain Ig rearrangementsSemantic proximity Read ↗

Somatic hypermutation of VHS107 genes is not associated with gene conversion among family members.Semantic proximity Read ↗

Structural analysis of substitution patterns in alleles of human immunoglobulin VH genes.Semantic proximity Read ↗

Evolutionary relationships and polymorphisms among V kappa 10 genes from inbred and wild-derived inbred mice.Semantic proximity Read ↗

Somatic diversity of the immunoglobulin repertoire is controlled in an isotype-specific manner.Semantic proximity Read ↗

What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?Semantic proximity Read ↗

Somatic origin of T-cell epitopes within antibody variable regions: significance to monoclonal therapy and genesis of systemic autoimmune disease.Semantic proximity Read ↗

Rearrangement of genetic information may produce immunoglobulin diversity.Semantic proximity Read ↗

Natural occurrence and origin of somatically mutated memory B cells in mice.Semantic proximity Read ↗

A VH12 transgenic mouse exhibits defects in pre-B cell development and is unable to make IgM+ B cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.