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Article

Structural analysis of substitution patterns in alleles of human immunoglobulin VH genes.

Molecular immunology - 1 May 2005

Romo-González Tania, Vargas-Madrazo Enrique

Abstract excerpt

The diversity in repertoires of antibodies (Abs) needed in response to the antigen challenge is produced by evolutionary and somatic processes. The mechanisms operating at a somatic level have been studied in great detail. In contrast, neither the mechanisms nor the strategies of diversification at an evolutionary level have yet been understood in similar detail. Particularly, the substitution patterns in alleles...

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Share to Immunoglobulin Variable Region
Share to Amino Acid Substitution
Share to Antibody Diversity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genes, Immunoglobulin

Share to Protein Structure, Tertiary

Share to Selection, Genetic

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 15829298
DOI: 10.1016/j.molimm.2004.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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