Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antibody repertoires generated by VH replacement and direct VH to JH joining.

Immunity - 1 Jul 2006

Koralov Sergei B, Novobrantseva Tatiana I, Königsmann Jessica, Ehlich Andreas, Rajewsky Klaus

Abstract excerpt

The immunoglobulin heavy chain repertoire is generated by somatic rearrangement of variable (V(H)), diversity (D(H)), and joining (J(H)) elements. It can be further diversified by V(H) replacement, where nonrearranged V(H) genes invade preexisting V(H)D(H)J(H) joints. To study the impact and mechanism of V(H) replacement, we generated mice in which antibody production depends on the replacement of a nonproductive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to B-Lymphocytes
Share to Gene Rearrangement, B-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homozygote

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin J-Chains

Share to Immunoglobulin Variable Region

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 16860756
DOI: 10.1016/j.immuni.2006.04.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antibody repertoires generated by VH replacement and direct VH to JH joining.PMID 16860756Read ↗

VH replacement rescues progenitor B cells with two nonproductive VDJ alleles.Semantic proximity Read ↗

Contribution of V(H) replacement products in mouse antibody repertoire.Semantic proximity Read ↗

Secondary mechanisms of diversification in the human antibody repertoireSemantic proximity Read ↗

Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes.Semantic proximity Read ↗

A mouse with a monoclonal primary immunoglobulin repertoire not further diversified by V-gene replacement.Semantic proximity Read ↗

VH gene replacement in hyperselected B cells of the quasimonoclonal mouse.Semantic proximity Read ↗

Antibody diversification by somatic mutation: from Burnet onwards.Semantic proximity Read ↗

The sequences encoded by immunoglobulin diversity (DH) gene segments play key roles in controlling B‐cell development, antigen‐binding site diversity, and antibody productionSemantic proximity Read ↗

Structure and evolution of mammalian V<sub>H</sub> familiesSemantic proximity Read ↗

Comparative analysis of human and mouse immunoglobulin variable heavy regions from IMGT/LIGM-DB with IMGT/HighV-QUEST.Semantic proximity Read ↗

An unusual type of V-J joining diversifies the primary repertoire of mouse lambda 1 light chains.Semantic proximity Read ↗

Receptor Revision of Immunoglobulin Heavy Chain Variable Region Genes in Normal Human B LymphocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.