Article
A VH12 transgenic mouse exhibits defects in pre-B cell development and is unable to make IgM+ B cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2001
Wang H, Ye J, Arnold L W, McCray S K, Clarke S H
Abstract excerpt
V(H)12 B cells undergo stringent selection at multiple checkpoints to favor development of B-1 cells that bind phosphatidylcholine. Selection begins with the V(H) third complementarity-determining region (CDR3) at the pre-B cell stage, in which most V(H)12 pre-B cells are selectively eliminated, enriching for those with V(H)CDR3s of 10 aa and a fourth position Gly (designated 10/G4). To understand this selection,...
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