Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rearrangement of genetic information may produce immunoglobulin diversity.

Nature - 1 Jan 2000

Weigert M, Gatmaitan L, Loh E, Schilling J, Hood L

Abstract excerpt

The nearly complete amino-acid sequences of 22 closely related immunoglobulin kappa variable (Vkappa) regions from the inbred NZB mouse are presented. This group of Vkappa regions is encoded by at least six germline Vkappa genes. These data also suggest that the mouse kappa gene is divided into three segments termed V or variable (residues 1 to 98 or 99), J or joining (residues 99 or 100 to 112) and C or constant...

Topics

Amino Acid Sequence
Animals
Antibody Specificity
Base Sequence
Binding Sites, Antibody
Genes
Immunoglobulin Light Chains
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred NZB

Mutation

Myeloma Proteins

Source

Identifiers

PMID: 103003
DOI: 10.1038/276785a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-103003-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rearrangement of genetic information may produce immunoglobulin diversity.PMID 103003Read ↗

Mechanistic and selective constraints act on the establishment of V lambda J lambda junctions in the B cell repertoire.Semantic proximity Read ↗

A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes.Semantic proximity Read ↗

The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strainsSemantic proximity Read ↗

Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity.Semantic proximity Read ↗

Germline diversity within the mouse Igk-V9 gene family.Semantic proximity Read ↗

Generation of the primary antibody repertoire in rabbits: expression of a diverse set of Igk-V genes may compensate for limited combinatorial diversity at the heavy chain locusSemantic proximity Read ↗

Most kappa immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes.Semantic proximity Read ↗

Allelic polymorphism of mouse Igh-J locus, which encodes immunoglobulin heavy chain joining (JH) segments.Semantic proximity Read ↗

Contribution of V(H) replacement products in mouse antibody repertoire.Semantic proximity Read ↗

Molecular characterization of J558 genes encoding tight-skin mouse autoantibodies: identical heavy-chain variable genes code for antibodies with different specificities.Semantic proximity Read ↗

Somatic hypermutation: mutations 3' of rabbit VDJ H-chain genes.Semantic proximity Read ↗

Variable region sequences of pathogenic anti-mouse red blood cell autoantibodies from autoimmune NZB mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.