Article
At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice.
Genetical research - 1 Oct 1994
Festing M F, Yang A, Malkinson A M
Abstract excerpt
Susceptibility to urethane-induced lung adenomas in mice has a polygenic mode of inheritance, with no obvious discontinuity in lung tumour counts among 37 AXB recombinant inbred strains. However, mean tumour counts were markedly higher in strains carrying the A/J allele at the Kras2 and H2 complex than in those carrying the C57BL/ allele. In 162 F2 hybrids and small numbers of both backcrosses between strain A/J...
Topics
- Adenoma
- Animals
- Base Sequence
- Crosses, Genetic
- Disease Susceptibility
- Female
- Genetic Markers
- Genetic Variation
- Lung Neoplasms
- Male
- Mice
- Mice, Inbred A