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Article

Cancer modifier alleles inhibiting lung tumorigenesis are common in inbred mouse strains.

International journal of cancer - 1 Jun 2002

Manenti Giacomo, Acevedo Abraham, Galbiati Federica, Giannì Barrera Roberto, Noci Sara, Salido Eduardo, Dragani Tommaso A

Abstract excerpt

Lung tumor susceptibility in inbred mouse strains is caused by the susceptibility allele at the pulmonary adenoma susceptibility 1 (Pas1(s)) locus. However, after urethane treatment, most strains carrying the Pas1(s) allele show an intermediate (1-4 tumors/mouse) instead of a highly susceptible (15-30 tumors/mouse) lung tumor phenotype. To test the hypothesis that strains displaying the intermediate lung tumor...

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Identifiers

PMID: 11992545
DOI: 10.1002/ijc.10386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cancer modifier alleles inhibiting lung tumorigenesis are common in inbred mouse strains.PMID 11992545Read ↗

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Pas1 is a common lung cancer susceptibility locus in three mouse strains.Semantic proximity Read ↗

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Genetic mapping of cancer susceptibility/resistance loci in the mouse.Semantic proximity Read ↗

Outbred CD-1 mice carry the susceptibility allele at the pulmonary adenoma susceptibility 1 (Pas1) locus.Semantic proximity Read ↗

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