Article
Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
Oncogene - 27 May 2004
Manenti Giacomo, Galbiati Federica, Giannì-Barrera Roberto, Pettinicchio Angela, Acevedo Abraham, Dragani Tommaso A
Abstract excerpt
The pulmonary adenoma susceptibility 1 (Pas1) locus affects inherited predisposition and resistance to chemically induced lung tumorigenesis in mice. The A/J and C57BL/6J mouse strains carry the susceptibility and resistance allele, respectively. We identified and genotyped 65 polymorphisms in the Pas1 locus region in 29 mouse inbred strains, and delimited the Pas1 locus to a minimal region of 468 kb containing...
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