Article
Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 1994
Devereux T R, Wiseman R W, Kaplan N, Garren S, Foley J F, White C M, Anna C, Watson M A, Patel A, Jarchow S
Abstract excerpt
Previous studies have hypothesized that at least three genetic loci contribute to differences in pulmonary adenoma susceptibility between mouse strains A/J and C57BL/6J. One gene that may confer susceptibility to lung tumorigenesis is the Kras protooncogene. To identify other relevant loci involved in this polygenic trait, we determined tumor multiplicity in 56 randomly chosen N-ethyl-N-nitrosourea-treated (A/J x...
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