Article
Epistatic interactions govern chemically-induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J chromosome substitution strains.
International journal of cancer - 1 Jan 2010
Dwyer-Nield Lori D, McQuillan Jay, Hill-Baskin Annie, Radcliffe Richard A, You Ming, Nadeau Joseph H, Malkinson Alvin M
Abstract excerpt
Cancer susceptibility results from interactions between sensitivity and resistance alleles. We employed murine chromosome substitution strains to study how resistance alleles affected sensitive alleles during chemically-induced lung carcinogenesis. The C57BL/6J-Chr#(A/J) strains, constructed by selectively breeding sensitive A/J and resistant C57BL/6J (B6) mice, each contain one pair of A/J chromosomes within an...
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