Developmental stage-specific cellular responses to vitamin D and glucocorticoids during differentiation of the osteoblast phenotype: interrelationship of morphology and gene expression by in situ hybridization.

Abstract excerpt

Fetal rat calvarial-derived osteoblasts, in vitro, undergo a developmental sequence of events leading to bone tissue-like organization and osteoblast differentiation. Previous studies have documented temporal expression of genes reflecting stages of osteoblast phenotype development in relation to tissue organization. Two steroid hormones are known to modify the developmental sequence; 1,25(OH)2D3 can block...

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