Article
Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes.
Journal of cellular biochemistry - 1 Dec 1992
Shalhoub V, Conlon D, Tassinari M, Quinn C, Partridge N, Stein G S, Lian J B
Abstract excerpt
To understand the mechanisms by which glucocorticoids promote differentiation of fetal rat calvaria derived osteoblasts to produce bone-like mineralized nodules in vitro, a panel of osteoblast growth and differentiation related genes that characterize development of the osteoblast phenotype has b...
Topics
- Alkaline Phosphatase
- Animals
- Bone and Bones
- Calcitriol
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Dexamethasone
- Gene Expression
- Glucocorticoids
- Osteoblasts
- Osteocalcin
- Osteopontin
- Phenotype
- RNA, Messenger