Article
Pleiotropic effects of vitamin D on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype: dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures.
Endocrinology - 1 Mar 1991
Owen T A, Aronow M S, Barone L M, Bettencourt B, Stein G S, Lian J B
Abstract excerpt
Normal rat osteoblasts in culture undergo a developmental sequence consisting of a proliferation period in which high levels of the histone and collagen type I genes are expressed, followed by periods of matrix maturation [high levels of alkaline phosphatase (AP)] and mineralization that signal a...
Topics
- Animals
- Bone Matrix
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Gene Expression Regulation
- Osteoblasts
- Phenotype
- Proteins
- Rats
- Reference Values
- Time Factors
- Vitamin D