The developmental stages of osteoblast growth and differentiation exhibit selective responses of genes to growth factors (TGF beta 1) and hormones (vitamin D and glucocorticoids).

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Article

The developmental stages of osteoblast growth and differentiation exhibit selective responses of genes to growth factors (TGF beta 1) and hormones (vitamin D and glucocorticoids).

The Journal of oral implantology - 1 Jan 1993

Lian J B, Stein G S

Abstract excerpt

Osteoblasts in vitro undergo a developmental sequence of growth and differentiation characterized by a stage-specific expression of cell growth and bone-related genes. Our studies show that contributions to development of the osteoblast phenotype include: (1) the down-regulation of proliferation, (2) biosynthesis and organization of type 1 collagen extracellular matrix, and (3) mineralization of this matrix....

Topics

Animals
Base Sequence
Bone Remodeling
Calcitriol
Cell Differentiation
Cells, Cultured
DNA
Dexamethasone
Extracellular Matrix
Glucocorticoids
Growth Substances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Molecular Sequence Data

Osseointegration

Osteoblasts

Osteocalcin

Osteogenesis

Phenotype

Source

Open in PubMed

Identifiers

PMID: 8246305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8246305-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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