Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix.

doi:10.1002/jcp.1041430304

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix.

Journal of cellular physiology - 1 Jun 1990

Owen T A, Aronow M, Shalhoub V, Barone L M, Wilming L, Tassinari M S, Kennedy M B, Pockwinse S, Lian J B, Stein G S

Abstract excerpt

The relationship of cell proliferation to the temporal expression of genes characterizing a developmental sequence associated with bone cell differentiation was examined in primary diploid cultures of fetal calvarial derived osteoblasts by the combined use of autoradiography, histochemistry, biochemistry, and mRNA assays of osteoblast cell growth and phenotypic genes. Modifications in gene expression define a...

Topics

Alkaline Phosphatase
Animals
Bone Development
Cell Differentiation
Cell Division
Collagen
Down-Regulation
Extracellular Matrix
Gene Expression
Histocytochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteoblasts

Osteopontin

Phenotype

RNA

Rats

Sialoglycoproteins

Source

Open in PubMed

Identifiers

PMID: 1694181
DOI: 10.1002/jcp.1041430304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1694181-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix.PMID 1694181Read ↗

Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation.Semantic proximity Read ↗

Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation.Semantic proximity Read ↗

Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation.Semantic proximity Read ↗

Developmental stage-specific cellular responses to vitamin D and glucocorticoids during differentiation of the osteoblast phenotype: interrelationship of morphology and gene expression by in situ hybridization.Semantic proximity Read ↗

Expression of cell growth and bone specific genes at single cell resolution during development of bone tissue-like organization in primary osteoblast cultures.Semantic proximity Read ↗

Expression of cell growth and bone phenotypic genes during the cell cycle of normal diploid osteoblasts and osteosarcoma cells.Semantic proximity Read ↗

TGF beta alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype.Semantic proximity Read ↗

Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype.Semantic proximity Read ↗

The developmental stages of osteoblast growth and differentiation exhibit selective responses of genes to growth factors (TGF beta 1) and hormones (vitamin D and glucocorticoids).Semantic proximity Read ↗

Development of the osteoblast phenotype in primary human osteoblasts in culture: comparison with rat calvarial cells in osteoblast differentiation.Semantic proximity Read ↗

Advances in the osteoblast lineageSemantic proximity Read ↗

Pleiotropic effects of vitamin D on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype: dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.