Article
Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein-DNA interactions at basal and enhancer promoter elements.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1993
Owen T A, Bortell R, Shalhoub V, Heinrichs A, Stein J L, Stein G S, Lian J B
Abstract excerpt
In the osteocalcin (OC) gene promoter, both independent positive and negative regulatory elements, as well as others with contiguous [TATA/glucocorticoid-responsive elements (GRE)] or overlapping [TATA/GRE, vitamin D-responsive enhancer elements (VDRE)/AP-1, and OC box/AP-1] domains, are sites fo...
Topics
- Animals
- Base Sequence
- Cell Division
- Cells, Cultured
- DNA
- DNA-Binding Proteins
- Dexamethasone
- Enhancer Elements, Genetic
- Humans
- Molecular Sequence Data
- Nuclear Proteins
- Oligodeoxyribonucleotides
- Osteoblasts