TGF beta alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype.

doi:10.1002/jcp.1041600214

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Article

TGF beta alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype.

Journal of cellular physiology - 1 Aug 1994

Breen E C, Ignotz R A, McCabe L, Stein J L, Stein G S, Lian J B

Abstract excerpt

This study examines the mechanism by which TGF-beta 1, an important mediator of cell growth and differentiation, blocks the differentiation of normal rat diploid fetal osteoblasts in vitro. We have established that the inability for pre-osteoblasts to differentiate is associated with changes in t...

Topics

Animals
Calcium
Cell Division
Diploidy
Extracellular Matrix
Gene Expression Regulation
Osteoblasts
Osteogenesis
Phenotype
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
RNA, Messenger
Rats
Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 8040190
DOI: 10.1002/jcp.1041600214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8040190-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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