Article
Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation.
The Iowa orthopaedic journal - 1 Jan 1995
Lian J B, Stein G S
Abstract excerpt
The formation of bone tissue involves multiple activities of the osteoblast. The combined application of molecular, biochemical, histochemical and ultrastructural approaches has defined stages in the development of the osteoblast phenotype with each subpopulation of cells exhibiting unique morpho...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cell Line
- Extracellular Matrix
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Histones
- Humans
- Osteoblasts
- Osteocalcin
- Osteosarcoma
- Phenotype
- Promoter Regions, Genetic
- Transforming Growth Factor beta