Article
Multiple levels of steroid hormone-dependent control of osteocalcin during osteoblast differentiation: glucocorticoid regulation of basal and vitamin D stimulated gene expression.
Journal of cellular biochemistry - 1 May 1998
Shalhoub V, Aslam F, Breen E, van Wijnen A, Bortell R, Stein G S, Stein J L, Lian J B
Abstract excerpt
We have examined the contribution of transcriptional mechanisms to the pleiotropic effects of glucocorticoids on basal and vitamin D stimulated expression of the developmentally regulated bone-specific osteocalcin (OC) gene. OC expression was systematically investigated at the level of protein, m...
Topics
- Animals
- Calcitriol
- Cell Differentiation
- Cells, Cultured
- Dexamethasone
- Fetus
- Gene Expression Regulation, Developmental
- Osteoblasts
- Osteocalcin
- Phenotype
- Protein Binding
- RNA, Messenger
- Rats
- Receptors, Calcitriol
- Receptors, Glucocorticoid