Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour.

doi:10.1038/362749a0

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Article

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour.

Nature - 22 Apr 1993

Ogawa O, Eccles M R, Szeto J, McNoe L A, Yun K, Maw M A, Smith P J, Reeve A E

Abstract excerpt

Genomic imprinting has been implicated in the onset of several embryonal tumours but the mechanism is not well understood. Maternal chromosome 11p15 loss of heterozygosity and paternal chromosome 11 isodisomy suggest that imprinted genes are involved in the onset of Wilms' tumour and the Beckwith...

Topics

Alleles
Base Sequence
Chromosomes, Human, Pair 11
DNA, Single-Stranded
Dosage Compensation, Genetic
Fathers
Female
Fetus
Heterozygote
Humans
Insulin-Like Growth Factor II
Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney Neoplasms

Male

Molecular Sequence Data

Mothers

Polymorphism, Restriction Fragment Length

RNA, Neoplasm

Source

Open in PubMed

Identifiers

PMID: 8097018
DOI: 10.1038/362749a0

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8097018-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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