Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas.

doi:10.1006/bbrc.1997.6744

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Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas.

Biochemical and biophysical research communications - 9 Jun 1997

Wu H K, Squire J A, Catzavelos C G, Weksberg R

Abstract excerpt

Breast cancer is the most frequent malignancy in women and genetically heterogeneous, and a variety of genetic lesions have been identified that tend to accumulate during the disease progress. In breast cancer, loss of heterozygosity (LOH) has been described in the critical regions of chromosomes 11p15 and 11q22-23. Genomic imprinting is defined as gamete specific modification causing differential expression of...

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Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas.

Abstract excerpt

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Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas.

Abstract excerpt

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