Article
Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas.
Biochemical and biophysical research communications - 9 Jun 1997
Wu H K, Squire J A, Catzavelos C G, Weksberg R
Abstract excerpt
Breast cancer is the most frequent malignancy in women and genetically heterogeneous, and a variety of genetic lesions have been identified that tend to accumulate during the disease progress. In breast cancer, loss of heterozygosity (LOH) has been described in the critical regions of chromosomes...
Topics
- Alleles
- Breast Neoplasms
- Chromosomes, Human, Pair 11
- DNA, Complementary
- Deoxyribonucleases, Type II Site-Specific
- Electrophoresis, Agar Gel
- Female
- Genomic Imprinting
- Heterozygote
- Humans
- Insulin-Like Growth Factor II
- Polymerase Chain Reaction
- Polymorphism, Genetic