Article
Relaxation of imprinted genes in human cancer.
Nature - 22 Apr 1993
Rainier S, Johnson L A, Dobry C J, Ping A J, Grundy P E, Feinberg A P
Abstract excerpt
Genomic imprinting, or parental allele-specific expression of genes, has been demonstrated at the molecular level in insects and mice but not in man. Imprinting as a potential mechanism of human disease is suggested by paternal uniparental disomy of 11p15 in Beckwith-Wiedemann syndrome and by mat...
Topics
- Alleles
- Base Sequence
- DNA, Single-Stranded
- Dosage Compensation, Genetic
- Fathers
- Female
- Fetus
- Humans
- Insulin-Like Growth Factor II
- Kidney Neoplasms
- Male
- Molecular Sequence Data
- Mothers
- Neoplasms
- Pedigree
- Wilms Tumor