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Article

Relaxation of imprinted genes in human cancer.

Nature - 22 Apr 1993

Rainier S, Johnson L A, Dobry C J, Ping A J, Grundy P E, Feinberg A P

Abstract excerpt

Genomic imprinting, or parental allele-specific expression of genes, has been demonstrated at the molecular level in insects and mice but not in man. Imprinting as a potential mechanism of human disease is suggested by paternal uniparental disomy of 11p15 in Beckwith-Wiedemann syndrome and by maternal uniparental disomy of 15q11-12 in Prader-Willi syndrome. Beckwith-Wiedemann syndrome is characterized by...

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Identifiers

PMID: 8385745
DOI: 10.1038/362747a0

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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