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Article

Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma.

Neoplasia (New York, N.Y.) - 1 Oct 1999

Anderson J, Gordon A, McManus A, Shipley J, Pritchard-Jones K

Abstract excerpt

Rhabdomyosarcomas are characterized by loss of heterozygosity (LOH) at chromosome region 11p15.5, a region known to contain several imprinted genes including insulin-like growth factor 2 (IGF2), H19, and p57(KIP2). We analyzed 48 primary tumour samples and found distinct genetic changes at 11p15.5 in alveolar and embryonal histological subtypes. LOH was a feature of embryonal tumours, but at a lower frequency...

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Source

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Identifiers

PMID: 10935489
DOI: 10.1038/sj.neo.7900052
PMCID: PMC1508094

Genes

IGF2
PAX3
PAX7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma.PMID 10935489Read ↗

Chromosome 11p15.5 regional imprinting: comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors.Semantic proximity Read ↗

Expression and parental imprinting of the H19 gene in human rhabdomyosarcoma.Semantic proximity Read ↗

Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors.Semantic proximity Read ↗

Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.Semantic proximity Read ↗

Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.Semantic proximity Read ↗

p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19.Semantic proximity Read ↗

Chromosomal rearrangements in the 11p15 imprinted region: 17 new 11p15.5 duplications with associated phenotypes and putative functional consequences.Semantic proximity Read ↗

p57K1P2 is expressed in Wilms' tumor with LOH of 11p15.5.Semantic proximity Read ↗

Relaxation of imprinted genes in human cancer.Semantic proximity Read ↗

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour.Semantic proximity Read ↗

Deletions and rearrangements of the H19/IGF2 enhancer region in patients with Silver-Russell syndrome and growth retardation.Semantic proximity Read ↗

Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity.Semantic proximity Read ↗

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