Article
Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors.
The Journal of clinical endocrinology and metabolism - 1 Aug 1997
Gicquel C, Raffin-Sanson M L, Gaston V, Bertagna X, Plouin P F, Schlumberger M, Louvel A, Luton J P, Le Bouc Y
Abstract excerpt
Abnormalities of the 11p15 region with overexpression of the normally imprinted insulin-like growth factor II (IGF-II) gene have been implicated in the pathogenesis of adrenocortical tumors. We evaluated the frequency and distribution of 11p15 loss of heterozygosity (LOH) and IGF-II gene overexpr...
Topics
- Adolescent
- Adrenal Cortex Neoplasms
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Biomarkers, Tumor
- Blotting, Southern
- Chromosome Aberrations
- Chromosomes, Human, Pair 11
- DNA Methylation
- Female
- Gene Deletion
- Gene Expression