Article
Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors.
The Journal of clinical endocrinology and metabolism - 1 Aug 1997
Gicquel C, Raffin-Sanson M L, Gaston V, Bertagna X, Plouin P F, Schlumberger M, Louvel A, Luton J P, Le Bouc Y
Abstract excerpt
Abnormalities of the 11p15 region with overexpression of the normally imprinted insulin-like growth factor II (IGF-II) gene have been implicated in the pathogenesis of adrenocortical tumors. We evaluated the frequency and distribution of 11p15 loss of heterozygosity (LOH) and IGF-II gene overexpression in a series of 82 sporadic adrenocortical tumors, screened for pathological functional imprinting of the 11p15...
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