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Article

Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity.

The Journal of biological chemistry - 1 Nov 1996

Wang W H, Duan J X, Vu T H, Hoffman A R

Abstract excerpt

Loss of imprinting of insulin-like growth factor-II gene (IGF2) and/or loss of heterozygosity at the 11p15 loci have been postulated to be responsible for IGF2 overexpression in Wilms' tumor. In order to delineate the mechanism of IGF2 overexpression in Wilms' tumors, we have genotyped the 11p15-11p13 chromosomal region and determined allelic expression of IGF2 and H19 in both tumor tissue and in normal adjacent...

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Source

Identifiers

PMID: 8910385
DOI: 10.1074/jbc.271.44.27863

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity.PMID 8910385Read ↗

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour.Semantic proximity Read ↗

Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors.Semantic proximity Read ↗

Relaxation of imprinted genes in human cancer.Semantic proximity Read ↗

Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas.Semantic proximity Read ↗

Multiple genetic abnormalities of 11p15 in Wilms' tumor.Semantic proximity Read ↗

Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms TumorSemantic proximity Read ↗

Loss of imprinting of igf2 in renal-cell carcinomas.Semantic proximity Read ↗

Genomic imprinting and carcinogenesis.Semantic proximity Read ↗

Genomic profiling maps loss of heterozygosity and defines the timing and stage dependence of epigenetic and genetic events in Wilms' tumors.Semantic proximity Read ↗

Alterations in the promoter-specific imprinting of the insulin-like growth factor-II gene in Wilms' tumor.Semantic proximity Read ↗

Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors.Semantic proximity Read ↗

Analysis of genomic imprinting of insulin-like growth factor 2 in colorectal cancer.Semantic proximity Read ↗

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