Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity.

doi:10.1074/jbc.271.44.27863

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Article

Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity.

The Journal of biological chemistry - 1 Nov 1996

Wang W H, Duan J X, Vu T H, Hoffman A R

Abstract excerpt

Loss of imprinting of insulin-like growth factor-II gene (IGF2) and/or loss of heterozygosity at the 11p15 loci have been postulated to be responsible for IGF2 overexpression in Wilms' tumor. In order to delineate the mechanism of IGF2 overexpression in Wilms' tumors, we have genotyped the 11p15-...

Topics

Alleles
Base Sequence
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 11
DNA Primers
DNA-Binding Proteins
Deoxyribonucleases, Type II Site-Specific
Gene Expression
Genomic Imprinting
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Like Growth Factor II

Kidney

Kidney Neoplasms

Molecular Sequence Data

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 8910385
DOI: 10.1074/jbc.271.44.27863

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8910385-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity.PMID 8910385Read ↗

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Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas.Semantic proximity Read ↗

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Genomic profiling maps loss of heterozygosity and defines the timing and stage dependence of epigenetic and genetic events in Wilms' tumors.Semantic proximity Read ↗

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Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors.Semantic proximity Read ↗

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