Article
Mono- and bi-allelic expression of insulin-like growth factor II gene in human muscle tumors.
Human molecular genetics - 1 Jul 1994
Pedone P V, Tirabosco R, Cavazzana A O, Ungaro P, Basso G, Luksch R, Carli M, Bruni C B, Frunzio R, Riccio A
Abstract excerpt
Insulin-like growth factor II (IGF-II) is a mitogen for many cell types and an important modulator of muscle growth and differentiation. IGF-II gene is prevalently expressed during prenatal development and its gene activity is regulated by genomic imprinting, in that the allele inherited from the father is active and the allele inherited from the mother is inactive in most normal tissues. IGF-II expression is...
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