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Article

Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas

25 Apr 2000

Abstract excerpt

Genomic imprinting is a reversible condition that causes parental-specific silencing of maternally or paternally inherited genes. Analysis of DNA and RNA from 52 human hepatocarcinoma samples revealed abnormal imprinting of genes located at chromosome 11p15 in 51% of 37 informative samples. The most frequently detected abnormality was gain of imprinting, which led to loss of expression of genes present on the...

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PMID: 10779553
DOI: 10.1073/pnas.090087497

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