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Article

Expression and parental imprinting of the H19 gene in human rhabdomyosarcoma.

Oncogene - 27 Mar 1997

Casola S, Pedone P V, Cavazzana A O, Basso G, Luksch R, d'Amore E S, Carli M, Bruni C B, Riccio A

Abstract excerpt

The expression of Insulin-like Growth Factor 2 (IGF-2) and H19, two genes located on human chromosome 11p15 and provided with cell growth modulating activity, is regulated by parental imprinting, in that the activity of their alleles is dependent on the parental origin. Parental bias in the genetic alterations of chromosome 11p15 observed in several pediatric cancers suggests the involvement of imprinted genes in...

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PMID: 9136994
DOI: 10.1038/sj.onc.1200956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Expression and parental imprinting of the H19 gene in human rhabdomyosarcoma.PMID 9136994Read ↗

Relaxation of imprinted genes in human cancer.Semantic proximity Read ↗

Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma.Semantic proximity Read ↗

Deletions and rearrangements of the H19/IGF2 enhancer region in patients with Silver-Russell syndrome and growth retardation.Semantic proximity Read ↗

The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas.Semantic proximity Read ↗

Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern.Semantic proximity Read ↗

Dissociation of IGF2 and H19 imprinting in human brain.Semantic proximity Read ↗

Mono- and bi-allelic expression of insulin-like growth factor II gene in human muscle tumors.Semantic proximity Read ↗

Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction.Semantic proximity Read ↗

Occasional loss of constitutive heterozygosity at 11p15.5 and imprinting relaxation of the IGFII maternal allele in hepatoblastoma.Semantic proximity Read ↗

The product of the imprinted H19 gene is an oncofetal RNA.Semantic proximity Read ↗

Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.Semantic proximity Read ↗

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastomaSemantic proximity Read ↗

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