Article
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16.
Nature - 8 Jun 1995
Lukas J, Parry D, Aagaard L, Mann D J, Bartkova J, Strauss M, Peters G, Bartek J
Abstract excerpt
D-type cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the G1 phase of the cell cycle by phosphorylating the retinoblastoma protein (RB). The activities of Cdk4 and Cdk6 are constrained by inhibitors such as p16, the product of the CDKN2 gene on human chromosome 9p21 (refs 12-14). The frequent deletion or mutation of CDKN2 in tumour cells suggests that p16 acts...
Topics
- Animals
- Carrier Proteins
- Cell Cycle
- Cells, Cultured
- Cloning, Molecular
- Cyclin D1
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase 6
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- Cyclins