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Article

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

26 Nov 1996

Abstract excerpt

Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence. The retinoblastoma gene product, Rb, expressed in these cells is hypophosphorylated. To determine a possible mechanism by which senescent human fibroblasts maintain a hypophosphorylated Rb, we examined the expression...

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PMID: 8943005
DOI: 10.1073/pnas.93.24.13742

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Source receipt: pubmed, retrieved 7 Sept 2026.

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