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Article

Regulation of p16<i><sup>CDKN2</sup></i> Expression and Its Implications for Cell Immortalization and Senescence

1 Mar 1996

Abstract excerpt

p16CDKN2 specifically binds to and inhibits the cyclin-dependent kinases CDK4 and CDK6, which function as regulators of cell cycle progression in G1 by contributing to the phosphorylation of the retinoblastoma protein (pRB). Human cell lines lacking functional pRB contain high levels of p16 RNA and protein, suggesting a negative feedback loop by which pRB might regulate p16 expression in late G1. By a combination...

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PMID: 8622687
DOI: 10.1128/mcb.16.3.859

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