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Article

Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines.

International journal of cancer - 29 Mar 1995

Aagaard L, Lukas J, Bartkova J, Kjerulff A A, Strauss M, Bartek J

Abstract excerpt

The p16Ink4/MTS1/CDKN2 is a cell-cycle regulatory inhibitor of cyclin-dependent kinase 4 (cdk4), and a candidate tumour suppressor whose gene on chromosome band 9p21 is frequently deleted or mutated in diverse types of cancer. Cdk4 in association with its D-type cyclin partners, together with p16...

Topics

Carrier Proteins
Cell Cycle
Chromosome Aberrations
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases
Genes, Retinoblastoma
Humans
Mutation
Neoplasms
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase Inhibitors

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins

RNA, Messenger

Tumor Cells, Cultured

Source

Identifiers

PMID: 7705923
DOI: 10.1002/ijc.2910610120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7705923-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines.PMID 7705923Read ↗

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Expression of the cyclin-dependent kinase inhibitors p16INK4, p15INK4B and p21WAF1/CIP1 in human breast cancer.Semantic proximity Read ↗

Growth suppression by p16ink4 requires functional retinoblastoma protein.Semantic proximity Read ↗

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