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Tumor suppressor p16 <sup>INK4A</sup> is necessary for survival of cervical carcinoma cell lines

17 Sept 2013

Abstract excerpt

The tumor suppressor p16(INK4A) inhibits formation of enzymatically active complexes of cyclin-dependent kinases 4 and 6 (CDK4/6) with D-type cyclins. Oncogenic stress induces p16(INK4A) expression, which in turn triggers cellular senescence through activation of the retinoblastoma tumor suppressor. Subversion of oncogene-induced senescence is a key step during cancer development, and many tumors have lost...

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PMID: 24046371
DOI: 10.1073/pnas.1310432110

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