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Article

p16 <sup> <i>INK4A</i> </sup> Participates in a G <sub>1</sub> Arrest Checkpoint in Response to DNA Damage

1 Jan 1998

Abstract excerpt

Members of the INK4 protein family specifically inhibit cyclin-dependent kinase 4 (cdk4) and cdk6-mediated phosphorylation of the retinoblastoma susceptibility gene product (Rb). p16INK4A, a prototypic INK4 protein, has been identified as a tumor suppressor in many human cancers. Inactivation of p16INK4A in tumors expressing wild-type Rb is thought to be required in order for many malignant cell types to enter S...

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Identifiers

PMID: 9418885
DOI: 10.1128/mcb.18.1.378

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p16 <sup> <i>INK4A</i> </sup> Participates in a G <sub>1</sub> Arrest Checkpoint in Response to DNA DamagePMID 9418885Read ↗

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