Article

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

2020-11-08

Abstract excerpt

Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence. The retinoblastoma gene product, Rb, expressed in these cells is hypophosphorylated. To determine a possible mechanism by which senescent human fibroblasts maintain a hypophosphorylated Rb, we examined the expression leve...

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Literature Corpus work: 1040bfa5-52f4-5cc0-84b9-3a5b8a6b4dc4
DOI: 10.17615/w1tk-be95

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