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Article

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.

Nature - 8 Jun 1995

Koh J, Enders G H, Dynlacht B D, Harlow E

Abstract excerpt

The cyclin-dependent kinase inhibitor p16 is a candidate tumour-suppressor protein that maps to a genomic locus strongly associated with familial melanoma and other tumour types. Screening of primary tumours and linkage analysis of familial melanoma pedigrees have identified many potential mutati...

Topics

3T3 Cells
Alleles
Animals
Carrier Proteins
Cell Line
Cyclin-Dependent Kinase Inhibitor p16
G1 Phase
Genes, Tumor Suppressor
Humans
Mice
Mutation
Protein Kinase Inhibitors
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 7777061
DOI: 10.1038/375506a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7777061-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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