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Article

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.

Nature - 8 Jun 1995

Koh J, Enders G H, Dynlacht B D, Harlow E

Abstract excerpt

The cyclin-dependent kinase inhibitor p16 is a candidate tumour-suppressor protein that maps to a genomic locus strongly associated with familial melanoma and other tumour types. Screening of primary tumours and linkage analysis of familial melanoma pedigrees have identified many potential mutations in p16, but the functional significance of these sequence variants has remained unclear. We report here that p16...

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PMID: 7777061
DOI: 10.1038/375506a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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