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Article

Growth suppression by p16ink4 requires functional retinoblastoma protein.

3 Jul 1995

Abstract excerpt

p16ink4 has been implicated as a tumor suppressor that is lost from a variety of human tumors and human cell lines. p16ink4 specifically binds and inhibits the cyclin-dependent kinases 4 and 6. In vitro, these kinases can phosphorylate the product of the retinoblastoma tumor suppressor gene. Thus, p16ink4 could exert its function as tumor suppressor through inhibition of phosphorylation and functional...

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Identifiers

PMID: 7603984
DOI: 10.1073/pnas.92.14.6289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Growth suppression by p16ink4 requires functional retinoblastoma protein.PMID 7603984Read ↗

Mutations and altered expression of p16INK4 in human cancer.Semantic proximity Read ↗

Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines.Semantic proximity Read ↗

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16.Semantic proximity Read ↗

The tumor suppressor protein p16INK4a.Semantic proximity Read ↗

p16 <sup> <i>INK4A</i> </sup> Participates in a G <sub>1</sub> Arrest Checkpoint in Response to DNA DamageSemantic proximity Read ↗

Expression of p16Ink4a Compensates for <i>p18Ink4c</i> Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and TissuesSemantic proximity Read ↗

Regulation of p16<i><sup>CDKN2</sup></i> Expression and Its Implications for Cell Immortalization and SenescenceSemantic proximity Read ↗

Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma.Semantic proximity Read ↗

Cyclin D1 Is Dispensable for G <sub>1</sub> Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 ActivitySemantic proximity Read ↗

Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cellsSemantic proximity Read ↗

Role of the INK4a locus in tumor suppression and cell mortality.Semantic proximity Read ↗

Transcriptional regulation of the CDK inhibitor p16INK4a gene by a novel pRb-associated repressor, RBAR1.Semantic proximity Read ↗

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