Article
Loss of heterozygosity on the short arm of chromosome 9 without p16 gene mutation in gastric carcinomas.
Japanese journal of cancer research : Gann - 1 Apr 1995
Sakata K, Tamura G, Maesawa C, Suzuki Y, Terashima M, Satoh K, Eda Y, Suzuki A, Sekiyama S, Satodate R
Abstract excerpt
A putative tumor suppressor gene, p16 (MST1; multiple tumor suppressor 1/CDK4I; cyclin-dependent kinase 4 inhibitor), was isolated and mapped on the short arm of chromosome 9 (9p). The significance of p16 mutations in gastric tumorigenesis was examined by assessing p16 mutations as well as loss o...
Topics
- Adenocarcinoma
- Adenoma
- Base Sequence
- Carrier Proteins
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p16
- DNA, Neoplasm
- Gene Deletion
- Genes, Tumor Suppressor
- Heterozygote
