Article
Loss of p16 (INK4A) expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected malignant peripheral nerve sheath tumors.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Mar 2006
Sabah Muna, Cummins Robert, Leader Mary, Kay Elaine
Abstract excerpt
The p16 is a tumor suppressor gene on the short arm of chromosome 9p21. The product of the p16 acts as a negative cell cycle regulator by inhibiting G1 cyclin-dependent kinases that phosphorylate the retinoblastoma protein. This study was designed to assess the frequency of genetic loss of 9p21 and to determine the role of p16 the pathogenesis of sporadic and neurofibromatosis 1 (NF1)-associated malignant...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Cells, Cultured
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p16
- Female
- Humans
- Immunohistochemistry
- Loss of Heterozygosity
- Male
- Middle Aged
- Nerve Sheath Neoplasms